Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

2,000.002,050.00

Author Name Dr. Abdullah Solaiman Aloraini, Mr. Abdulkarim SAI-Humaid, Mr. Ghalib Abdulah Alghamdi, Ms. Taibah Abdulrazag Alhumaid
Book Format e-Book
Categories Medicine & Science
Language English
Pages 387
Published Date 11-NOV.-2023
Size B5
ISBN
Clear

Multiple sclerosis has a high genetic association signal at chromosome 6p21.3, in the major histocompatibility complex (MHC). About 160 related genes are clustered in this 4-megabase area. “Six classic transplantation human leukocyte antigen (HLA) genes play crucial roles in immunological control (12). These are the class I HLA- A, HLA-B, and HLA-C genes, and the class II HLA-DPB1, HLA-DQB1, and HLA-DRB1 genes.” There have been over 15,000 different alleles discovered for HLA genes so far.

This means that HLA genes are very variable. In 1972, using serological reagents, researchers discovered an increase in the frequency of surface glycoproteins encoded by the HLA-A3 and HLA-B7 class I alleles in MS patients (13, 14), providing the first evidence of a link between HLA and MS risk. “In the years that followed, several studies were conducted, and the connection between the HLA locus and MS risk was independently repeated across all populations tested, in both primary progressive and relapsing-remitting patients. Better powered research, including genome-wide association studies (GWAS), have indicated that the predominant MS susceptibility signal throughout the genome maps to the HLA-DRB1 gene in the class II area of the MHC, despite the fact that the first connection was to class I HLA-A and HLA-B alleles. The biggest impact is from the HLA-DRB1*15:01 variant, with an average odds ratio of 3.08 and a clear dosage response to zero, one, or two copies of the allele carried by a person. It has also been shown that the class I area of the locus is subject to complicated allelic hierarchical lineages, cis/trans-epistatic and haplotypic effects, and separate protective signals.

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Author Name

Dr. Abdullah Solaiman Aloraini, Mr. Abdulkarim SAI-Humaid, Mr. Ghalib Abdulah Alghamdi, Ms. Taibah Abdulrazag Alhumaid

Book Format

e-Book

Categories

Medicine & Science

Language

English

Pages

387

Published Date

11-NOV.-2023

Size

B5

ISBN

Author's Details

Dr. ABDULLAH SOLAIMAN ALORAINI, internal medicine specialist. I currently work in Prince Sultan Military Medical City, a graduate of Al-Imam University in the city of Riyadh. I believe that medical education is one of the basics and duties of a doctor. I am pleased to present this simple work and I hope that it will be useful to the honorable reader regarding patients with multiple sclerosis.

Mr. GHALIB ABDULAH ALGHAMDI, Neuro rehabilitation Manager Rehabilitation Services at King Abdulaziz Medical City, Riyadh. KSA.

MS, TAIBAH ABDULRAZAG ALHUMAID, Physiotherapist at King Abdulaziz Medical City, Riyadh, KSA.

MR. ABDULKARIM SAI-HUMAID Presently working as Chief Physical Therapist (Clinical supervisor) with more than 24 years of experience In the field of Neurological Physiotherapy. lie holds his Bachelor and Master’s degree in physiotherapy in Neurology from King Saud University- Riyadh Kingdom of Saudi Arabia. His special interest in Neurological and spinal cord injuries patients. The list ofseminars and training he attended cannot be ignored. He also associated as one of teaching faculty member for Diploma program for physiotherapy at Health Studies. He published many articles in International journals.

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